Open eTrust InoculateIT by going to Start -> Programs -> eTrust InoculateIT -> eTrust InoculateIT
You do not have to adjust the settings if you already did so. Click here if you didn't do that.
Check off the drive that you want scanned (C:) or (A:).
Push the green arrow on the top left. If you are checking the (C:) drive, this may take about 30 minutes.